Trial registrationĬhineses Clinical Trial Register, ChiCTR-ONC-17010654. In summary, epidural analgesia may be safe for both mother and neonate in the three studied hospitals. The labor duration of multiparas was increased, but within acceptable range. ConclusionsĮpidural analgesia could reduce labor pain, and no increased risk of postpartum bleeding or uterine rupture, as well as adverse effects in newborns were observed. After matching by PSM, multivariable logistic regression revealed that the correction of confounding factors including epidural analgesia, cervical Bishop score at admission and spontaneous onset of labor were still shown as promotion probability in study group (OR = 4.480, 1.360, and 10.188, respectively 95%CI = 2.025–10.660, 1.113–1.673, and 2.875–48.418, respectively p < 0.001, p = 0.003, and p < 0.001, respectively). It also showed more superiority in neonatal umbilical arterial blood pH value. Epidural analgesia significantly shortened initiating lactation period and declined Visual Analogue Score (VAS). The success rate of VBAC was remarkably higher (85.55% vs. Maternal delivery outcomes and neonatal characteristics were recorded and evaluated using univariate analysis, multivariable logistic regression and propensity score matching (PSM). Multiparas were divided into two groups according to whether they received epidural analgesia (study group, N = 263) or not (control group, N = 160) during labor. MethodsĪ total of 423 multiparas undergoing TOLAC were enrolled in this study from January 2017 to February 2018. This study aimed to evaluate the effect of epidural analgesia on primary labor outcome, parturient complications and neonatal outcomes after TOLAC in Chinese multiparas based on a strictly uniform TOLAC indication, management and epidural protocol. The trial of labor after cesarean section (TOLAC) is a relatively new technique in mainland of China, and epidural analgesia is one of the risk factors for uterine rupture.
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